Health officials said they are investigating where and how the latest cases of monkeypox in England acquired their infection.
People who might have been in close contact with either case are being contacted and given information and health advice, the UK Health Security Agency said.
Dr Colin Brown, director of clinical and emerging infections at the UKHSA, said: “We have confirmed two new monkeypox cases in England that are not linked to the case announced on May 7.
“While investigations remain ongoing to determine the source of infection, it is important to emphasise it does not spread easily between people and requires close personal contact with an infected symptomatic person.
“The overall risk to the general public remains very low.
“We are contacting any potential friends, family or contacts in the community. We are also working with the NHS to reach any healthcare contacts who have had close contact with the cases prior to confirmation of their infection, to assess them as necessary and provide advice.”